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FINE
Fluorinated PLGA-PEO dendrImers as 19F MRI Nanotheranostics for ostEosarcoma management
Principal investigator: Monica Montesi
Personnel involved: Silvia Panseri, Giada Bassi, Arianna Rossi, Mohamed Saqawa
Starting date: 16/10/2023
Duration: 24 months
Total funding: 225.680,00 €
Action: PRIN: PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE – Bando 2022
CNR-ISSMC role: Partner
Coordinator: Prof. Angela Scala (Università di Messina)
Consortium: 2 partners
FINE project aims to synthesize new fluorinated dendrimers based on poly(lactide-co-glycolic acid) (PLGA) and poly(ethylene oxide) (PEO) combining amphiphilic properties, controllable functionalities, pH-sensitive hydrazone units and high content of chemically equivalent fluorine atoms, with the aim to develop novel pH-responsive drug nanocarriers and 19F-MRI nanoprobes (NanoDenFluo) for osteosarcoma management. The activity of ISSMC is related to evaluating the NanoDenFluo biological performances in a more predictive 3D scaffold-based cancer model, recapitulating more in detail the complexity of the cancer tissue in vivo and reducing the limitation of the standard in vitro
2D culture systems.