Bio-inspired bone regeneration

Principal Investigator: Simone Sprio
Involved Personnel: Monica Sandri

Administrative management/reporting: Laura Mengozzi

Starting date: 01/10/2013
Duration: 48 mesi
Total funding: 3.807.345 €
Action: PITN-GA-2013-607051
Project coordinator: Ian Bouwstra (Fujifilm Manufacturing Europe B.V., The Netherlands)
Consortium: Fujifilm Life Science (NL), CNR-ISTEC (IT), Fraunhofer Institute (DE), Erasmus MC (NL), University of Bologna (IT), Medicyte (DE), Bone Therapeutics (BE).

BIO-INSPIRE will develop a new horizon in Orthopaedic Therapy by:

  1. Development of a technology platform that consists of new bio-active and bio-mimetic materials and their therapeutic applications for bone regenerative purposes.
  2. Training of the next generation of leading Tissue Engineering scientists in a multi-disciplinary way, leading them towards excellence in individual disciplines in combination with a multidisciplinary, holistic view on the (bone tissue) biological systems to be studied.

The consortium consists of a unique alliance of carefully selected Partners with a high reputation in a set of complementary disciplines (as required for a multi-disciplinary program in the field of bone regeneration) consisting of Fraunhofer, Medicyte (field of Cell therapy), Fujifilm Life Science (Bio-Materials), CNR-ISTEC (Bone Mineralisation), Erasmus MC (Growth Factors), University of Bologna, Bone Therapeutics (Orthopaedic Therapy).
This combination provides a unique multidisciplinary research environment for 16 hosted Fellows.
The industrial participation is high, being the coordinator and chairing the project and hosting 8 Fellows out of 16 Fellows, immersing those Fellows in both an academic and an industrial research setting.
This project will provide:

  • A new generation of scientists, capable to participate in multi-disciplinary, pan-European project teams, mastering their individual disciplines in combination with a multi-disciplinary, holistic view.
  • A new class of bio-material prototypes, bio-mimetic, triggering cascades of bone regenerative processes, ready for clinical trials beyond BIO-INSPIRE for a variety of therapeutic needs.
  • A robust pan-European network for development of bio-mimetic materials, consisting of Academic and Industrial participants, acting as an European Network for Innovation and Education for talented scientists in the field of tissue regenerative technologies and medical therapies.


  • Fernandes Patricio TM, Panseri S, Montesi M, Iafisco M, Sandri M, Tampieri A, Sprio S (2019). Superparamagnetic hybrid microspheres affecting osteoblasts behaviour. J Mater Sci Eng B 96: 234-247.
  • Shankar KG, Gostynska N, Dapporto M, Campodoni E, Montesi M, Panseri S, Tampieri A, Kon E, Marcacci M, Sprio S, Sandri M. (2018) Evaluation of different crosslinking agents on hybrid biomimetic collagen-hydroxyapatite composites for regenerative medicine. Int. J. Biol Macromol 106, 739-748.
  • Gostynska N, Gopal Shankar K, Campodoni E, Panseri S, Montesi M, Sprio S, Kon E, Marcacci M, Tampieri A, Sandri M. (2017) 3D porous collagen scaffolds reinforced by glycation with ribose for tissue engineering application. Biomed Mater 12(5):055002. doi: 10.1088/1748-605X/aa7694.
  • Ramírez-Rodríguez GB, Montesi M, Panseri S, Sprio S, Tampieri A, Sandri M. Biomineralized recombinant collagen-based scaffold mimicking native bone enhances mesenchymal stem cell interaction and differentiation (2017) Tissue Eng part A. 23(23-24):1423-1435. doi: 10.1089/ten.tea.2017.0028.
  • Fernandes Patricio TM, Panseri S, Sandri M, Tampieri A, Sprio S. (2017) New bioactive bone-like microspheres with intrinsic magnetic properties obtained by bio-inspired mineralization process. Mat Sci Eng C 77: 613-623.
  • Shankar KG, Gostynska N, Campodoni E, Dapporto M, Montesi M, Panseri S, Tampieri A, Kon E, Marcacci M, Sprio S, Sandri M (2017). Ribose-mediated crosslinking of collagen-hydroxyapatite hybrid scaffolds for bone tissue regeneration using biomimetic strategies. Mater Sci Eng C, 77: 594-605.
  • Shankar KG, Gostynska N, Montesi M, Panseri S, Sprio S, Kon E, Marcacci M, Tampieri A, Sandri M. (2017) Investigation of different cross-linking approaches on 3D gelatin scaffold for tissue engineering application: a comparative analysis. Int J Biol Macromol 95, 1199-1209.
  • Ramírez-Rodríguez GB, Delgado-López JM, Iafisco M, Sandri M, Sprio S, Tampieri A. (2016) Biomimetic mineralization of recombinant collagen type I derived protein to obtain hybrid matrices for bone regeneration. J Struct Biol. 196(2) 138-146. doi: 10.1016/j.jsb.2016.06.025.
  • Ramirez-Rodriguez GB, Delgado-Lopez JM, Montesi M, Panseri S, Sandri M, Sprio S, Tampieri A. Nanoscale design of bone scaffolds through biomineralization process modulating cell behaviour. (2015) Tissue Eng Part A; 21: S274-S274.
  • Fernandes Patricio TM, Sprio S, Sandri M, Montesi M, Panseri S, Tampieri A. Hybrid superparamagnetic collagen-like peptide microparticles applied on bone tissue regeneration. (2015) Tissue Eng Part A; 21: S152-S152.
  • Gostynska N, Krishnakumar G, Kon E, Sandri M, Sprio S, Panseri S, Montesi M, Marcacci M, Tampieri A. (2015) Hydrophilic crosslinking strategies of gelatin scaffolds for tissue engineering applications. Tissue Eng Part A; 21: S245-S245.