WO 2012/063201 (A1) – Implants for “load-bearing” bone substitutions having hierarchical organized architecture deriving from transformation of vegetal structures

Reference: WO 2012/063201 (A1)
Inventors: Simone Sprio, Anna Tampieri, Monica Sandri, Silvia Panseri, Giandomenico Logroscino
Applicants: Consiglio Nazionale delle Ricerche (90 %); Università Cattolica di Roma (10%)
Filing date: 19.06.2014
Contact: Simone Sprio


The patent protects a biomorphic transformation process whereby a natural structure is chemically transformed into a silicon carbide scaffold. The plant involves the construction of a core-shell structure in which the core is a fibrous construct based on mineralized collagen with hydroxyapatite made by means of a biomineralization process, and the shell is given by the silicon carbide structure.
The patent is granted in EU and USA.